Eyelid CareBlephaDerm®

BlephaDerm®

A soothing eyelid and eye contour cream that hydrates, protects, and repairs the delicate eyelid skin that supports ocular health.

Triple-action relief

BlephaDerm® features an innovative trio of natural ingredients to provide relief for sensitive, dry, irritated and allergy-prone eyelid skin. Trehalose provides bioprotection1 and regenerates the skin moisture barrier,2,3 hyaluronic acid provides hydration and offers immediate comfort,4,5 and Ophiopogon Japonicus soothes and repairs dry skin,5,6 supporting your eyelid microbiota.

Gentle, soothing care

The perfume-free and preservative-free formula hydrates, protects and repairs.6 It provides relief from itching, enhances the skin moisture barrier and natural defences, and delivers both immediate and long-lasting hydration.

Apply BlephaDerm® every day—morning and night—on cleansed skin.

Gently smooth onto both upper and lower eyelids from the inner corner outwards

Gently dab onto both upper and lower eyelids from the inner corner outwards

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Your eyelid skin is unique7

Thin7

Eyelid skin is among the thinnest on the body, allowing for the delicate movements but providing less natural protection.

Sensitive

Packed with nerve endings and containing fewer oil glands, it can react quickly to irritants, allergens, and changes in the environment.

Fragile

With very little cushioning beneath the surface, eyelid skin is more susceptible to dryness, sun damage, and early signs of ageing.

Common risk factors that can affect your delicate eyelid skin8,9

Preservatives

Allergens

Harsh cosmetic products

Excessive skin washing

Topical eye drops

Signs and symptoms of damaged eyelid skin

Itching and redness10

Crusting10

Dryness and burning10

Under-eye puffiness and dark circles9-11

A healthy and balanced eyelid microbiome ensures healthy eyelid skin11
  • Millions of bacteria, fungi and viruses are living on the eyelids12
  • A balanced microbiome contributes to the barrier function of the skin12
  • Each person’s microbiome is unique13

BlephaDerm® is patient preferred

In ophthalmological and dermatological clinical studies, patients reported significant improvements in:14–16

Under-eye puffiness14

77% of patients reported under-eye puffiness was decreased after 28 days15

Skin brightness15

86% of patients reported significantly improved eye contour skin colour14

Irritation15

Irritation was immediately reduced at 10 minutes, with a 95% reduction at 28 days15

Skin uniformity14

86% of patients reported significantly improved skin uniformity14

Itching15

Itching was significantly reduced at 10 minutes, with a 94% reduction at 28 days15

Moisture16

Moisturizing effect was still significantly increased after 8 hours16

Discomfort15

Discomfort was immediately reduced at 10 minutes, with a 92% reduction at 28 days15

Combined power to manage your dry eyes

1 Cleanse

BlephaClean®

2 Relief

Blepha EyeBag®

3 Repair & Protect

BlephaDerm®

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Have questions about whether this product is right for you?

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References:
  1. Jain NK, et al. Effect of trehalose on protein structure. Protein Sci. 2009;8(1):24–36.
  2. Čejkova J, et. al. Trehalose treatment accelerates the healing of UVB-irradiated corneas. Comparative immunohistochemical studies on corneal cryostatsections and corneal impression cytology. Histol Histopathol. 2012;27(8):1029–1040.
  3. Li J, Robieux C, et. al. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Mol Vis. 2012;18:317–329.
  4. Juncan AM, et. al. Advantages of hyaluronic acid and its combination with other bioactive ingredients in cosmeceuticals. Molecules. 2021;26(15):4429.
  5. Mainzer C, et. al. Clinical efficacy of oligofructans from Ophiopogon japonicus in reducing atopic dermatitis flare-ups in Caucasian patients. Acta Derm Venereol. 2019;99(10):858–864.
  6. Messaraa C, et. al. Can performance and gentleness be reconciled? A skin care approach for sensitive skin. Cosmetics. 2022;9(2):34.
  7. Pratchyapruit W, et. al. Functional analyses of the eyelid skin constituting the most soft and smooth area on the face: contribution of its remarkably large superficial corneocytes to effective water-holding capacity of the stratum corneum. Skin Res Technol. 2007;13(2):169–175.
  8. Craig JP, et al. TFOS DEWS II Definition and Classification Report. The Ocular Surface. 2017;15:276–283.
  9. Sullivan DA, et al. TFOS Lifestyle: Impact of cosmetics on the ocular surface. Ocul Surf. 2023;29:77–130.
  10. Jourdan M, et al. Skin care management for medical aesthetic procedures to prevent scarring. Clin Cosmet Investig Dermatol. 2019;12:799–804.
  11. Johnson JL. The human skin microbiome and its changes in atopic dermatitis. September 28, 2022. Accessed October 29, 2023. https://nationaleczema.org/blog/microbiome-and-atopic-dermatitis/.
  12. Aragona P, et al. The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders. Surv Ophthalmol. 2021;66(6):907–925.
  13. Carvalho MJ, et. al. Skin microbiota and the cosmetic industry. Microb Ecol. 2023;86(1):86–96.
  14. Data on file. Thea Pharma Inc. Clinical Study Report 182458: Clinical evaluation of the cutaneous and ocular acceptability and efficacy of a cosmetic product. Final report v1.0; January 18, 2019.
  15. Data on file. Thea Pharma Inc. Clinical Study Report 22E1350: Clinical evaluation of the cutaneous and ocular acceptability and efficacy of a cosmetic product in care of atopic skin. Final report v1.0; December 1, 2022.
  16. Data on file. Théa Pharma Inc. Clinical Study Report 22E1351: Biometrological evaluation of the transepidermal water loss effect and a long-lasting moisturizing effect of a cosmetic product. Final report v1.0; July 5, 2022.
  17. Peral A, et al. Importance of Lid Hygiene Before Ocular Surgery: Qualitative and Quantitative Analysis of Eyelid and Conjunctiva Microbiota. Eye & Contact Lens: Science & Clinical Practice. 2016;42(6):366–70.