Ocular Surface Thealoz Duo®

Looking for Thealoz Duo Gel?

Thealoz Duo®

The only artificial tear with a unique combination* of trehalose and hyaluronic acid† that is clinically proven to address the root cause of Dry Eye Disease and restore the natural ecosystem of the eye.1,2

Dry eye management

Long-lasting dry eye relief that maintains the health of the eye’s surface, reduces the signs of inflammation3 and restores the eye’s normal environment.1,2

Two proven therapies in one bottle

The only artificial tear with a unique combination of 2 active ingredients—trehalose (3%), to stabilize and restore the tear film, and hyaluronic acid† (0.15%) for hydration.

Preservative-free

Thealoz Duo® is preservative- and phosphate-free,
making it suitable for regular use by those with dry eyes, and compatible with all types of contact lenses.

Easy to use

The flexible and ergonomic ABAK® bottle ensures easy and precise application, while maintaining a sterile environment. Each bottle contains 300 single doses, 
which can be used up to 6 months after opening.1

Read the study

Use Thealoz Duo® as needed and as directed by your eyecare professional—as part of an eyecare routine for those diagnosed with Dry Eye Disease.

Gently stretch the lower eyelids

Apply one drop in each eyelid pocket

Close both eyes

Watch Video

 
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  • Thealoz Duo®
  • Hyaluronic acid
  • Sodium chloride

Adapted from Schmidl, et al. (2015)1

Thealoz Duo® extends dry eye relief

Relative tear film thickness over time after instillation of Thealoz Duo®, hyaluronic acid† and sodium chloride. With over 20 published clinical papers, Thealoz Duo® has demonstrated improved benefits—including increased tear film thickness. After 10 minutes, Thealoz Duo® increased tear film thickness by 40% more than hyaluronic acid alone (29% vs. 21%).§ Thealoz Duo® maintained a significant increase in tear film thickness for nearly 4 hours, almost 6 times longer than hyaluronic acid alone.§

Thealoz Duo® reduces 
inflammatory markers

The root cause of Dry Eye Disease is linked to inflammation—after only 2 months, inflammatory markers are reduced by an average of 58%.

Low Molecular Weight Hyaluronic Acid + Trehalose resists eye blinking, mimics natural tears and ensures better spreading on the ocular surface.4

1 drop of 0.5 mL of TD with LMHWA

After eye blinking

Adapted from Caretti, et al. (2019)7

Thealoz Duo® is designed 
to mimic natural tears

Thealoz Duo® is formulated with synergistically paired 3% Trehalose & 0.15% (Low Molecular Weight) Hyaluronic Acid.4 This combination resists eye blinking, mimics natural tears and ensures a better spreading on the ocular surface.

Percentage of patients in moderate and severe OSDI classes 
  • Thealoz Duo®
  • Sodium hyaluronate

Adapted from Chiambaretta, et al. (2016)5

Thealoz Duo® reduces
dry eye symptoms

After only 5 weeks of treatment, patients using Thealoz Duo® experienced a 60% reduction in moderate to severe OSDI (Ocular Surface Disease Index) scores—nearly twice the improvement seen with hyaluronic acid alone (36%).

Additionally, 1 in 4 patients treated with Thealoz Duo® reported complete relief from dry eye symptoms.

Thealoz Duo® Gel

The benefits of Thealoz Duo®—enhanced with carbomer for longer-lasting tear film protection.

Long-lasting comfort

Stabilizes tear film thickness for 6 hours.6

Gentle after-surgery care

Demonstrated a statistically significant improvement in tear film stability and ocular discomfort, compared to sodium hyaluronate after cataract surgery.7

Supports healthy eye hydration

Restores normal osmotic balance.

Relief for dry eyes

Provides bioprotection and osmoregulation to relieve dry eyes.

All-day care

Complements Thealoz Duo® for daytime and nighttime use.||

Use Thealoz Duo® Gel as needed and as directed by your eyecare professional—as part of an eyecare routine for those diagnosed with Dry Eye Disease.

Gently stretch the lower eyelids

Apply one drop in each eyelid pocket

Close both eyes

Supporting eye comfort and recovery

Thealoz Duo® Gel reduces tear film instability and ocular surface discomfort after cataract surgery.7

Combined power to manage your dry eyes

1 Protect

Thealoz Duo®

2 Cleanse

BlephaClean®

3 Relief

Blepha EyeBag®

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  • *Combination of sodium hyaluronate and trehalose as two active ingredients only.
  • †As sodium hyaluronate salt 0.15%
  • ‡Significant versus baseline for Thealoz Duo®
  • §Significant versus baseline for hyaluronic acid
  • ||If you wear contact lenses, you must remove them before using Thealoz Duo® Gel. After using Thealoz Duo® Gel, wait at least 30 minutes before putting your lenses back in.
References:
  1. Schmidl D, et al. Tear Film Thickness After Treatment with Artificial Tears in Patients with Moderate Dry Eye Disease. Cornea. 2015;34(4):421–6.
  2. Mencucci R, et al. Hyaluronic acid/trehalose ophthalmic solution in reducing post-cataract surgery dry eye signs and symptoms: A prospective, interventional, randomized, open-label study. JCM. 2021;10(20):4699.
  3. Fariselli C, et al. Trehalose/hyaluronate eyedrop effects on ocular surface inflammatory markers and mucin expression in dry eye patients. Clinical Ophthalmology. 2018;12:1293–1300.
  4. Data on file. Laboratoires Théa, 2025. Updated 2023.
  5. Chiambaretta F, Doan S, Labetoulle M, et al. A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome. Eur J Ophthalmol. 2017;27(1):1-9. doi:10.5301/ejo.5000836.
  6. Wozniak PA, et al. Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography. Acta Ophthalmol. 2017;95(4):e307–13.
  7. Caretti L,et al. Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery. 2019:13 1157–1163.